
State Hospital and the railroad hub of Anna anchor the northwestern portion of this Southern Illinois landscape, surveyed during the first decades of the twentieth century. The terrain is defined by the winding course of the Cache River and its numerous tributaries, including Cypress Creek and Mill Creek, which shaped the placement of local settlements and farmsteads. The regional economy is clearly marked by the competing rail lines of the Illinois Central and the Chicago and Eastern Illinois, which converge at junctions like Ullin and Joppa Junction.
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